20 June 2008

Optus Installs Ciscos Conferencing Suite

Optus Installs Ciscos Conferencing Suite

By Branko Miletic | Friday | 2008-06-20

Optus has deployed Australia's first multipoint Cisco TelePresence solution, with systems in two locations in Sydney and a third in Melbourne. Cisco TelePresence is an "in-person" meeting experience over a converged network. It delivers real-time face-to-face interactions between people and places, using advanced visual, audio and collaboration technologies.

Click to enlarge
These technologies transmit life-size, high-definition images and spatial discrete audio, which gives users the ability to discern facial expressions for business discussions and negotiations across the "virtual table."

John Simon, Managing Director, Optus Business said; "The Cisco TelePresence implementation provides Optus with a multitude of benefits for our business, our staff, and our customers. Already, we have experienced a significant reduction in travel for the Optus senior leadership team since deploying the solution. Not only will the technology help us to reduce travel and its associated costs but it will also provide us with a proven solution to demonstrate to customers and prospects."

The multipoint TelePresence System 3000 gives Optus employees the ability to employ up to 48 systems in different locations. A three-screen Cisco TelePresence System 3000 unit for six participants on one side of the virtual table has been implemented at the Optus Macquarie Park campus in Sydney and in Optus' Melbourne office.

Optus is also deploying Cisco's TelePresence System 500 at its Macquarie Park campus. This personal Cisco TelePresence system retains the same qualities of the ‘in-person', lifelike, interaction while giving organizations the flexibility to support intimate, one-on-one meetings and enable employees to join larger group meetings from personal workspaces. The deployment of all four Cisco TelePresence systems at Optus will allow up to 15 users to collaborate between Sydney and Melbourne.

Les Williamson, vice president of Cisco Australia and New Zealand, said: "Networking technologies, particularly those that use video such as Cisco TelePresence, are playing a critical role in the evolution of business as it becomes more collaborative and productive. Optus will benefit from its deployment of Cisco TelePresence in terms of encouraging collaboration and reducing the impact and cost of its travel."

20 May 2007

Mini DNA replicator could benefit world's poor


A pocket-sized device that runs on two AA batteries and copies DNA as accurately as expensive lab equipment has been developed by researchers in the US.



The device has no moving parts and costs just $10 to make. It runs polymerase chain reactions (PCRs), to generate billions of identical copies of a DNA strand, in as little as 20 minutes. This is much faster than the machines currently in use, which take several hours.

"I hope this will make PCR more available," says Victor Ugaz of Texas A&M University in Texas, US, whose group made the new device. He says the system could enable DNA-based tests to be carried out in the field or in developing countries, where large, expensive laboratory equipment is neither practical nor affordable.

Running a PCR requires treating DNA strands, along with chemical materials needed to make new DNA strands, at three different temperatures. The highest temperature (95°C) causes two strands of a DNA molecule to separate. The lowest temperature (60°C) makes DNA building blocks stick together. Then, holding the temperature in the middle (72°C), allows an enzyme to quickly assemble replica DNA strands.

Facsimile machine

To cycle through these temperatures, a conventional PCR machine heats and cools a large metal block holding multiple tubes containing samples of DNA and the material needed to make copies.

In the new device, created by graduate student Nitin Agrawal, a centimetre-wide loop of tubing wraps in a vertical ring around a set of three metal rods. The rods, together the size of an AA battery, are kept at three different temperatures. With this set-up, the parts of the tube closest to each block are heated differently.

This keeps the liquid flowing through the millimetre-wide tube, and so the DNA and building blocks cycle automatically through the three temperatures needed for PCR. "It's similar to how a lava lamp works," says Ugaz.

As the fluid is heated, it becomes less dense and more buoyant, so it flows upward. When the fluid cools in another part of the loop, it becomes denser and moves down. And because the device only heats the three small blocks of metal, it also runs off just two AA batteries.

Incomplete solution

"This is a significant advance in the proof of the concept," says biomedical engineer Samuel Sia of Columbia University in New York, US. "It shows you can use convection-driven flow to do PCR in a miniaturized format."

The device shows promise for a variety of tests, Sia says, including monitoring levels of HIV virus in a person's body or diagnosing tuberculosis. "There's nothing like this in developing countries," he explains. "There's a great need everywhere in the world for doing DNA- and RNA-based tests."

For the full potential of the device to be realised, however, Sia says that cheap and simple methods of preparing samples, by isolating DNA from cells, will be needed along with miniaturised DNA analysis equipment.

Journal reference: Angewandte Chemie International Edition (DOI: 10.1002/anie.200700306)

30 April 2007

Scientists beat internet speed record

Scientists beat internet speed record

Japanese researchers have sent data over the internet at a speed of 9.08GB/s - which would allow a user to download a film in 4 seconds

The prospect of downloading a feature film in seconds came a step closer today after Japanese scientists announced they had achieved a new speed record for transferring data over the internet.

The record - which involved sending a stream of data over a 30,000km network, the equivalent of three quarters of the earth’s circumference - achieved a speed of 9.08 GB/s, about 1,000 times faster than current top of the range broadband connections.

At that speed, a full-length feature film of 1.5 GB would be downloaded in matter of seconds. Most household broadband connections would take more than 40 minutes to download a film.

The benefits were not likely to be felt by regular internet users any time soon, however, because the record was set using a custom-built fibre optic network, which enables speeds far greater than the copper cables through which most homes connect to the internet.

It also used a ‘next generation’ internet protocol called IPv6, which has several benefits over the current protocol, IPv4, but is yet to be widely rolled out.

The researchers led by a team at the University of Tokyo set the record in December last year over a network which stretched from Tokyo to Chicago, on to Amsterdam, and then back to Tokyo via Seattle, a distance of 32, 372km.

For a period 20 minutes on a night they knew net traffic would be at a low - New Year's Eve - they streamed data at a speed of 9.08 GB/s, surpassing the previous record of 8.8 GB/s, which was set in February last year.

Dr Kei Hiraki, professor of computing science at the University of Tokyo who led the research, said: "These records are final for the 10GB/s network era because they represent more than 98% of the upper limit of network capacity.”

The increased speed had resulted from "several technical improvements," Dr Hiraki said, including more precise "pacing" of data and better "buffering capability," which resulted in less "packet loss."

The 'path' used for the record was custom-built fibre optic network used by universities and government agencies for research purposes.

A spokeswoman for internet2, a US-based consortium which helped develop the network, said that it was currently in the process of being upgraded to allow speeds of 100GB, which would allow films to be downloaded in fractions of a second.

"In order to deliver those kinds of speeds to consumers, however, you're talking about a significant investment in the existing infrastructure, and that's something that has to come from the network providers," the spokeswoman said.

Dr Hiraki said that he expected to achieve speeds of 40GB within 2 years, and 100GB in 6 years.

Asked whether he was already working on the next record attempt, he said: "Of course. But the method is still confidential."

23 April 2007

Blogger Bar :: Firefox Add-ons

Blogger Bar :: Firefox Add-ons

Hey guys don't use this one use the Google Bar instead.

Find it under Add Ons on the Mozilla.org website.

Craig

05 March 2007

Fact or Fiction?: Living People Outnumber the Dead

Fact or Fiction?: Living People Outnumber the Dead
Booming population growth among the living, according to one rumor, outpaces the dead
By Ciara Curtin





LIVING VERSUS DEAD: The Earth may seem crowded with 6.5 billion people but it would take 100 billion living to come close to outnumbering all who have ever lived.
The human population has swelled so much that people alive today outnumber all those who have ever lived, says a factoid whose roots stretch back to the 1970s. Some versions of this widely circulating rumor claim that 75 percent of all people ever born are currently alive. Yet, despite a quadrupling of the population in the past century, the number of people alive today is still dwarfed by the number of people who have ever lived.

In 2002 Carl Haub, a demographer at the Population Reference Bureau, a nongovernmental organization in Washington, D.C., updated his earlier estimate of the number of people that have ever existed. To calculate this, he studied the available population data to determine the human population growth rates during different historical periods, and used them to determine the number of people who have ever been born.

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For most of history, the population grew slowly, if at all. According to the United Nations' Determinants and Consequences of Population Trends, the first Homo sapiens appeared around 50,000 years ago, though this figure is debatable. Little is known about this distant past and how many of us there might have been, but by the time of the agricultural revolution in the Middle East in 9000 B.C., Earth held an estimated five million people.

Between the rise of farming and the height of Roman rule,population growth was sluggish; at less than a tenth of a percent per year, it crawled to about 300 million by A.D. 1. Then the total fell as plagues wiped out large swathes of people. (The "black death" in the 14th century wiped out at least 75 million.) As a result, by 1650 the world population had only increased to about 500 million. By 1800, though, thanks to improved agriculture and sanitation, it doubled to more than one billion. And, in 2002 when Haub last made these calculations, the planet's population had exploded, reaching 6.2 billion.

To calculate how many people have ever lived, Haub followed a minimalist approach, beginning with two people in 50000 B.C.—his Adam and Eve. Then, using his historical growth rates and population benchmarks, he estimated that slightly over 106 billion people had ever been born. Of those, people alive today comprise only 6 percent, nowhere near 75 percent. "[It is] almost surely true people alive today are some small fraction of [all] people," says Joel Cohen, a professor of populations at the Rockefeller and Columbia Universities in New York City.

For this myth ever to be valid there would have to be more than 100 billion people living on Earth. "How cozy," Cohen says. "It just doesn't seem plausible," he adds.

Today there are more than 6.5 billion people walking on Earth, according to United Nations estimates. Recently, the population has been increasing by about 1.2 percent each year, down from the late 1960s peak of a 2.1 percent yearly growth rate. Some industrialized countries, especially France and Japan, have very low birth rates and their populations are actually dwindling, Haub notes. In developing nations populations continue to grow, but some countries, such as India, are experiencing a slowdown in their growth rate.

Cohen doubts that a doubling of today's population, to 13 billion, will occur, never mind approaching anywhere near 100 billion. Not even the U.N.'s highest projection predicts that much growth, he says. For 2050, the world body's estimates range from 7.3 billion to 10.7 billion people. The median, and most likely, projection of 8.9 billion relies on a gradual slowing of the growth rate. And the U.N. predicts the world population will stabilize at 10 billion inhabitants sometime after 2200. At this rate, the living will never outnumber the dead

05 January 2007

Cancer cure patented

Cancer cure patented
Submitted by Vidura Panditaratne on Thu,:16. SciTech | United States | Non-geographical | News

Breast Cancer cellBreast Cancer cell

A group of researchers claim that they are patenting a possible cure for cancer involving nothing more than sugar and short-chain fatty acid combination. [ Chemistry & Biology]

The Johns Hopkins researchers cautioned that their double-punch molecule, described in the December issue of the journal Chemistry & Biology, has not yet been tested on animals or humans.

Nevertheless, they believe it represents a promising new strategy for fighting the deadly disease, and have already filed an application for a U.S. patent covering this class of compounds.

"For a long time, cancer researchers did not pay much attention to the use of sugars in fighting cancer," Department of Biomedical Engineering postdoctoral fellow said. "But we found that when the right sugar is matched with the right chemical partner, it can deliver a powerful double-whammy against cancer cells."

Sampathkumar and his colleagues built upon 20-year-old findings that a short-chain fatty acid called butyrate can slow the spread of cancer cells. In the 1980s, researchers discovered that butyrate, which is formed naturally at high levels in the digestive system by symbiotic bacteria that feed on fibre, can restore healthy cell functioning.

Efforts to use butyrate as a general drug for tumours elsewhere in the body have been hindered by the high doses of the compound needed to effectively eradicate cancer leading scientists to try and make butyrate more potent by modifying it or joining it to other compounds.

The results have been disappointing because the molecular partner added to butyrate to improve delivery to the cancer cells often produced unsafe side effects.

In some of the less successful experiments, designed to avoid toxic side effects, researchers used innocuous sugar molecules such as glucose to carry butyrate into the cells.

"We didn't think they chose the right partner molecule," said Kevin J. Yarema, an assistant professor of biomedical engineering who supervised the project. "Our insight was to select the sugar partner to serve not just as a passive carrier but as additional ammunition in the fight against cancer."

The researchers focused on a sugar called N-acetyl-D-mannosamine, or ManNAc, for short, and created a hybrid molecule by linking ManNAc with butyrate.

The hybrid easily penetrates a cell's surface, then is split apart by enzymes inside the cell.

Once inside the cell, ManNAc is processed into another sugar known as sialic acid that plays key roles in cancer biology, while butyrate orchestrates the expression of genes responsible for halting the uncontrolled growth of cancer cells.

Although the study of the exact molecular mechanism is in its early stages, the researchers believe the separate chemical components work together to bolster the cancer-fighting power of butyrate.

The double attack triggers cellular suicide, also called apoptosis, in the cancer cells.

To find out whether this butyrate-ManNAc hybrid alone would produce the positive results, the researchers tested three other sugar-butyrate combinations and a butyrate salt compound with no sugar attached.

The four other formulas and the butyrate-ManNAc hybrid were each added to lab dishes containing cancer cells.

After three to five days, cancer growth had slowed in all of the dishes.

After 15 days, cancer growth had resumed in dishes treated with four of the compounds, but in samples treated with the butyrate-ManNAc hybrid, all of the cancer cells had died.

The researchers also wanted to find out whether administering the two parts of the hybrid independently would achieve the same result, but in these experiments, the cancer cells did not self-destruct.

The researchers suspect this is because the hybrid molecules more easily penetrate the surface of the cell than the individual chemicals.

Once the components are inside, the researchers believe the partners help enzymes to resume the normal assembly of sugar molecules and correct aberrant gene expression patterns, two processes that go awry when cancer occurs.

11 November 2006

Fortune - "Get Employees to Brainstorm Online"

A growing number of big companies are taking advantage of the Internet, plus specially designed software, to run brainstorming sessions.
By Anne Fisher

If you're like most managers, you know you've hired some pretty smart people. Still, the suggestion boxes you have scattered around the place are gathering nothing but cobwebs, and in the daily rush of getting the work done, it's hard to find time to encourage would-be innovators to speak up. According to a study by PricewaterhouseCoopers, almost half (45%) of lucrative ideas—whether breakthrough products or services, new uses for old ones, or ways to cut costs—come from employees. (Customers, suppliers, and competitors contribute the other half.) How can you make sure you're not squandering any in-house brainpower? A growing number of big companies, including Georgia-Pacific, W.R. Grace, Sun Life Financial, and ChevronTexaco, are taking advantage of the Internet, plus specially designed software, to run brainstorming sessions that allow people at far-flung locations to "meet" online and hash out solutions to particular problems. The technology lets employees see, and build on, one another's ideas, so that one person's seed of a notion can grow into a practical plan.

It seems to work. Says Paul Westgate, director of innovation at W.R. Grace: "Before we started doing this, in 2001, we had no systematic way of developing new ideas." Since then, Grace's chemical-manufacturing division has run 34 online campaigns to solicit employee suggestions. From those efforts a total harvest of 2,685 ideas has yielded 76 new products and 67 distinct improvements in how things get done. Some employees, responding to a campaign called Customers Do the Darndest Things, reported that customers were telling them about unexpected uses for existing products, leading the company into new markets that have boosted annual revenues by as much as $3 million. "To make online brainstorming effective, ask only those specific questions to which you really want answers," says Westgate. "Then be ready to act on them."

At Georgia-Pacific, for example, rather than ask for general cost-cutting ideas, management zeroed in on shaving the cost of the cardboard tubes inside rolls of paper towels. Senior operations manager Jeremy Wren notes that the company spends about $30 million a year on the components, which the "consumer really doesn't care about." Thanks to the speed of the online system, mill workers from among the company's 16,000 North American employees quickly responded with little changes that shaved about $1.2 million a year, or roughly 4%, off the cost of the tubes. Of course, not every idea is a winner. Says Wren: "We've gotten responses ranging from the interesting to the bizarre."

Mark Turrell, an Intel alumnus, is CEO of Boston-based Imaginatik, which makes the software Grace and Georgia-Pacific use. "More companies are trying to manage innovation as they manage every other important business process," he says. "So it will become a race to see who does it best." By his lights, it comes not a minute too soon. "In the global economy America isn't the low-cost producer, so you need great brainpower," he says. "Where else is your value added?" Where indeed?

The 12 Different Ways for Companies to Innovate

The 12 Different Ways for Companies to Innovate
Mohanbir Sawhney, Robert C. Wolcott and Inigo Arroniz
Topic: Management of Technology and Innovation
Reprint 47314; Spring 2006, Vol. 47, No. 3, pp. 75-81

Faced with the prospects of slow growth, commoditization and global competition, companies like General Electric Co., Microsoft Corp. and Ford Motor Co. have now emphasized innovation as critical to their future success. But what exactly is innovation? Although the subject has risen to the top of the CEO agenda, many companies have a mistakenly narrow view of it. They might see innovation as synonymous with new product development or traditional research and development. But such myopia can lead to the systematic erosion of competitive advantage. As a result, companies in a given industry can come to resemble one another over time. In actuality, business innovation is far broader in scope than product or technological innovation. In fact, a company can innovate along any of 12 different dimensions with respect to its (1) offerings, (2) platform, (3) solutions, (4) customers, (5) customer experience, (6) value capture, (7) processes, (8) organization, (9) supply chain, (10) presence, (11) networking, and (12) brand. Nissan Motor Co., for example, has innovated along the platform dimension, using essentially the same small engine block to power a variety of models, including an upscale midsize sedan, a large sedan, luxury sedans, a minivan and a sports coupe. Enterprise Rent-A-Car has innovated along the customers and presence dimensions, placing car rental locations in the neighborhoods where people live and work rather than at airports. Together the 12 dimensions of innovation can be displayed in a new framework called the “innovation radar,” which companies can use to manage the increasingly complex business systems through which they add value.

Mohanbir Sawhney is the McCormick Tribune Professor of Technology and the director of the Center for Research in Technology & Innovation at Northwestern University’s Kellogg School of Management in Evanston, Illinois. Robert C. Wolcott is a fellow and adjunct professor and Inigo Arroniz is a postdoctoral fellow at the Center for Research in Technology & Innovation.

Managing Innovation in Small Worlds

Managing Innovation in Small Worlds
A brief synopsis of Managing Creativity in Small Worlds (California Management Review, summer 2006) by Lee Fleming and Matt Marx
Topic: Management of Technology and Innovation
Reprint 48104; Fall 2006, Vol. 48, No. 1, pp. 8-9

Innovation is typically a group effort, but how exactly do researchers collaborate with one another to innovate? To answer this question, the authors compiled a dataset identifying all co-authorship relationships of U.S. patent inventors from 1975 through 1999.

That dataset revealed that the social network of innovators is a “small world,” with various clusters of people interconnected by different “gatekeepers,” individuals who bridge one group with another. Historically, engineers and scientists tended to work within local clusters of collaboration that were isolated within a company. Recently, though, people have become increasingly mobile, changing jobs with greater frequency, and these formerly isolated clusters have begun to interconnect into larger networks through which information flows more freely between companies. Such environments provide both strategic opportunity and potential threat: They can increase creativity within a company, but they also aid in the diffusion of creative knowledge to other firms through personnel and knowledge transfer. The trick, then, is to manage innovation in ways that exploit the opportunities while minimizing the risks.

10 crucial elements of building an innovative company

10 crucial elements of building an innovative company

By Jim Miller, Executive Vice President, Products and Technologies Organization, Cadence Design Systems

Innovation is a major driver of today’s world economy, enabling the introduction of new products that fuel top-line growth for those companies that are good at generating original and novel ideas. Few industries and sectors have relied on innovation as a key element of growth and business strategies more than technology and electronics companies.
A significant portion of the innovation power driving technology can be attributed to the entrepreneurs who have an idea and pursue the dream of seeing it realized. This highly visible phenomenon may lead some people to think that innovation is the sovereign territory of startups and new ventures. This is simply not true. I have found through my experience at successful startups as well as large, industry-leading public companies that innovation and entrepreneurs can thrive in both environments.
There are several obvious but essential elements of a company’s culture that can promote innovation. These elements are not outside the grasp of any company, regardless of size, but do require continuous efforts to keep the innovation engine working. Because they seem obvious, it is often assumed that they are in place and are therefore often overlooked by management.

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1. Champion innovation. Management must identify and empower formal and informal leaders to champion innovation through specific programs and initiatives. Although the CEO remains the key innovation driver in organizations, “innovation champions” keep the efforts visible to the organization. Recently some new roles. such as Google’s chief innovation officer, have emerged in the corporate structure to augment the traditional chief technology officer. Special titles are not required, but clear support for—and expectations of—innovation leaders by the senior management ranks is. This signals that innovation is no longer the domain of technology but a priority strategy for numerous companies, no longer just a technology effort but also a critical business practice.
2. Hire smart people. At the risk of stating the obvious, fill your organization with the most intelligent and experienced employees you can find. This foundation of talent will lead to a multiplying effect as the best and brightest share with and build off each other’s ideas. One of the underappreciated advantages of globalization is that it provides access to the intelligent and highly educated talent available worldwide, much of which is in close proximity to customers, from whom many of the best ideas flow. As these global centers of excellence develop critical mass, they will, in turn, establish their role in the company-wide innovation network.
3. Share ideas, methods and technologies. Create formal opportunities to share information across the organization to build an internal innovation network. Cadence sponsors two internal technology conferences—one in India and one in North America—to allow R&D teams to share technical papers, tutorials and ideas with their peers. The conference proceedings alone represent thousands of hours of innovation. However, the biggest value is the informal networking and exchange that occur during the breaks, dinners, and social activities, all of which foster the building of networks within the organization.
4. Establish an entrepreneurial environment. Ideas can come from anywhere in the organization but need guidance from the leadership team. Give every idea and its “entrepreneur” an objective hearing by the management team. The entrepreneur should then work with a member of the management team to analyze the idea in terms of strategic direction and business opportunities. Well-developed ideas supported by analytical data are designated as “strategic discussions” that are evaluated by the applicable executive team—product line or corporate strategy—for further direction and funding decisions.
5. Make innovation a mission. Once an innovation project is identified, give the innovators the freedom to pursue the project. Larger companies have the financial strength and functional resources to establish incubator projects that relieve the team from day-to-day responsibilities of the business, allowing complete focus on the project goals. Even when an exclusive project is not possible or required, making innovative results part of the measurement of an ongoing program helps drive desirable behaviors.
6. Establish vision and deadlines. Innovation thrives where there is a disciplined approach to quality and commitments. Give people the vision in terms of the “what” and “why,” followed by the “when needed,” to be relevant to the business. My experience bears out a management axiom that most of the measurable results occur in the last 20 percent of the remaining time. The manager of the innovation process can control the pace of innovation through the thoughtful establishment of milestones. The milestone intervals should be set sufficiently wide apart to achieve the next demonstrable step toward the desired result but sufficiently close together to create focus for the team.
7. Measure innovation through metrics. Another axiom is the setting of goals that capture the desired results of the proposed innovation. For example, EDA software innovation has technical performance measures relative to the accuracy of results, computational and elapsed runtime, memory usage, and user productivity and usability. The goals can be set sufficiently high to challenge the team for breakthrough innovation but measured in small calendar increments to demonstrate progress.
8. Offer rewards and recognition. The organization needs to provide incentives and motivations to foster innovation. Reward and recognition programs are essential to spotlight and reinforce behaviors that promote idea sharing; collaboration; teamwork; and, of course, results. For example, instant-reward programs can encourage employees and managers to recognize daily behaviors of colleagues, such as assisting at a critical time in a program or contributing market data that supports an entrepreneur’s strategic discussion preparation. Other elements of such programs can range from cash bonuses for invention disclosures and patent filings to special compensation programs for the most-innovative employees and a significant financial stake in the business success of particular innovations.
9. Leverage the external innovation network. There are numerous resources outside of your company that can provide the catalyst or breakthrough for significant innovations. For example, Cadence leverages ongoing relationships with universities, partners, and customers to extend its innovation network by identifying the need for particular innovations, pooling intellectual talent, and sharing financial costs.
10. Don’t forget the bottom line. In addition to product innovations fueling top-line growth, there are always opportunities in business model innovation and process innovation to influence the bottom line. Business model innovations allow large companies to reach untapped or underserved markets for zero or modest increases in operating costs. Managers and product line executives are also encouraged to identify process and product innovations that improve operational efficiencies. The results of these operational efficiencies can be returned to the corporation for additional profits or reinvested in the strong pipeline of entrepreneurial projects that will generate even more top-line growth.

31 October 2006

Experts crack cancer 'gene codes'

Experts crack cancer 'gene codes'

Faulty genes help cancers grow
US scientists have cracked the entire genetic code of breast and colon cancers, offering new treatment hopes.
The genetic map shows that nearly 200 mutated genes, most previously unknown, help tumours emerge, grow and spread.

The discovery could also lead to better ways to diagnose cancer in its early, most treatable stages, and personalised treatments, Science magazine reports.

The Johns Hopkins Kimmel Cancer Center says the findings suggest cancer is more complex than experts had believed.

Distinct differences

The mutated genes in breast and colon cancers were almost completely distinct, suggesting very different pathways for the development of each of these cancer types.

Each individual tumour appeared to have a different genetic blueprint, which could explain why cancers can behave very differently from person to person, the scientists said.

"No two patients are identical," co-author Dr Victor Velculescu explained.


Scientists hope to be able to tailor plans for preventing or treating cancer to each person's individual genetic profile
Ed Yong of Cancer Research UK

Now researchers will study how these mutations occur in breast and colon cancers.

Previous cancer gene discoveries have already led to successful detection and treatment strategies.

For example, the breast cancer drug Herceptin targets a breast cancer cell receptor made by the Her2-neu gene. Blood tests for hereditary bowel cancer are based on the APC gene.

Personalised therapies

Dr Anna Barker, of the National Cancer Institute, said: "Maximising the numbers of targets available for drug development in a specific cancer means that patients will ultimately receive more personalised, less toxic therapies."

Ed Yong, of Cancer Research UK, commented: "This is potentially a very important piece of research.

"Most of the cancer genes identified in this study have not been previously linked to cancer.

"These newly identified genes could provide rich hunting grounds for scientists looking for new ways of treating or detecting cancers.

"In the future, scientists hope to be able to tailor plans for preventing or treating cancer to each person's individual genetic profile. Studies like this can help us to accomplish this goal."

26 October 2006

Electronic chip, interacting with the brain, modifies pathways for controlling movement

Electronic chip, interacting with the brain, modifies pathways for controlling movement

Mechanism may have potential in stroke and brain injury rehabilitation

Researchers at the University of Washington (UW) are working on an implantable electronic chip that may help establish new nerve connections in the part of the brain that controls movement. Their most recent study, to be published in the Nov. 2, 2006, edition of Nature, showed such a device can induce brain changes in monkeys lasting more than a week. Strengthening of weak connections through this mechanism may have potential in the rehabilitation of patients with brain injuries, stroke, or paralysis.

The authors of study, titled "Long-Term Motor Cortex Plasticity Induced by an Electronic Neural Implant," were Dr. Andrew Jackson, senior research fellow in physiology and biophysics, Dr. Jaideep Mavoori, who recently earned a Ph.D. in electrical engineering from the UW, and Dr. Eberhard Fetz, professor of physiology and biophysics. For many years Fetz and his colleagues have studied how the brains of monkeys control their limb muscles.

When awake, the brain continuously governs the body's voluntary movements. This is largely done through the activity of nerve cells in the part of the brain called the motor cortex. These nerve cells, or neurons, send signals down to the spinal cord to control the contraction of certain muscles, like those in the arms and legs.

The possibility that these neural signals can be recorded directly and used to operate a computer or to control mechanical devices outside of the body has been driving the rapidly expanding field of brain-computer interfaces, often abbreviated BCI. The recent Nature study suggests that the brain's nerve signals can be harnessed to create changes within itself.

The researchers tested a miniature, self-contained device with a tiny computer chip. The devices were placed on top of the heads of monkeys who were free to carry out their usual behaviors, including sleep. Called a Neurochip, the brain-computer interface was developed by Mavoori for his doctoral thesis.

"The Neurochip records the activity of motor cortex cells," Fetz explained, "It can convert this activity into a stimulus that can be sent back to the brain, spinal cord, or muscle, and thereby set up an artificial connection that operates continuously during normal behavior. This recurrent brain-computer interface creates an artificial motor pathway that the brain may learn to use to compensate for impaired pathways."

Jackson found that, when the brain-computer interface continuously connects neighboring sites in the motor cortex, it produces long-lasting changes. Namely, the movements evoked from the recording site changed to resemble those evoked from the stimulation site.

The researchers said that a likely explanation for these changes is the strengthening of pathways within the cortex from the recording to the stimulation site. This strengthening may have been produced by the continuous synchronization of activity at the two sites, generated by the recurrent brain-computer interface.

Timing is critical for creating these connections, the researchers said. The conditioning effect occurs only if the delay between the recorded activity and the stimulation is brief enough. The changes are produced in a day of continuous conditioning with the recurrent brain-computer interface, but last for many days after the circuit is turned off.

"This unusually long-lasting plasticity may be related to the fact that the conditioning is associated with normal behavior," Fetz said.

24 October 2006

$1.65 Billion Innovation and Counting

$1.65 Billion Innovation and Counting

When was the last time a company innovated from zero to $1.65 Billion in market value in less than two years from founding, and in less than one year from launch of their key product?

Beginnings of a new Broadcast company

YouTube, a consumer media company for people to watch and share original videos worldwide, serves over 70 million videos daily on their website - videos that are created and shared by everyday people. YouTube also draws 34 million unique visitors a month, ranking it in the top 15 sites by traffic volume. YouTube's mission is to convert everyday people into broadcasters of tomorrow. Is YouTube the beginning of a new broadcast company? A company that fundamentally changed the rules where people choose what they want to watch, when they want to watch, and for how much (and free in most cases) without the overload of advertisements.

Who came first?

Is YouTube a modern-day community of all the people who were using Microsoft's NetMeeting for sharing live video many years ago? There was a huge wave of people who initially embraced the live capability of sharing video in NetMeeting in the late nineties using a simple Webcam and simultaneously conducting conferencing using integrated live chat and audio. A market of live conferencing and video sharing softwares got created overnight based on this initial success. Some of the applications of live video even created a whole new adult industry. However, not a single vendor experienced any type of consumer mass market success. And then TIVO emerged from the Internet boom (or bust), wherein you can buy a simple hardware device (technically a large hard-drive that saved analog TV broadcast into digitial media) and pause, rewind and store live broadcast TV, and watch it on demand anytime. TIVO was innovative and revolutionary, and single-handedly created a huge market following for On demand TV. TIVO even became a verb wherein thousands of TV fans would talk about "Just Tivo it." However, TIVO was a personal device that did not let you share the videos with friends and families. Nor TIVO allowed you to capture your own video and store it (at least not easily) and then send it someone else.

New Innovations

Until Steve Jobs and Apple started the iPod and then iTunes revolution, which morphed into video downloads of hit TV shows onto iPods or desktops to allow people to view the shows on demand. However, even the brilliantly innovative Jobs missed what was to become a people Video revolution. Whereas Jobs was focused on creating partnerships with TV broadcast companies to monetize the market of recorded broadcast videos and grow the business at Apple, YouTube founders Chad Hurley, Steve Chen, and Jawed Karim were focused on the exact opposite - free video service created by the people for the people. They were trying to create the world's best platform and Video network wherein people can upload, tag and share videos for free. The founders almost went broke trying this innovative experiment out after the launch when the number of people uploading videos to share, and the number of people downloading videos to watch grew exponentially. However, the growth of Internet as a network and the fall in price of broadband, bandwidth and storage kept their vision going (and a few million dollar capital investment eventually by Sequoia capital). The YouTube Innovation Revolution was just beginning.

Zero to 70 million Videos served daily

YouTube, founded in February 2005, created many timely innovations that made it successful in such a short time paving its way to an acquisition by Google for $1.65 Billion dollars.

First, the vision of Founders to create a Video download service for FREE (and not getting caught up in monetizing the Video Service from the get go) at the right time when the broad consumer market was evolving into creating and sharing home videos at personal websites or community sites from just sharing pictures and images. Sound familiar? Think Google (that created the Search engine for free and did not monetize it for the longest time).

Second, the intense focus on providing the best and most comprehensive experience for users interested in uploading, watching and sharing videos. This is no easy feat. YouTube made it as easy as 1,2,3 to upload and share a video. And to create a vibrant community, it added such key features as categories, video ratings, most requested videos, most watched videos, and more. This made it extremely easy even for a novice to simply go to YouTube site and browse a video that they want to watch at the click of a mouse. And the ease of uploading and sharing videos meant that there was always fresh content that people want to watch daily. People can also create their own accounts and create their own list of favorite videos, categories, etc. Of course to make all these possible, YouTube created an innovative seamless Video platform that can deliver hundreds of millions of Video to people all over the world.

Finally, YouTube created key partnerships with various Music and Broadcast players in the industry (who soon realized that YouTube was upto something big). This included CBS, Sony, Universal, Warner, NBC and more. This gave YouTube and its people ability to watch snippets of TV shows, news, movies, sports and entertainment shows - short-form video programming or short clips. This became a win-win for both YouTube and its partners. YouTube wins because it brings in fresh content from hundreds of broadcast channels that people around the world want to watch online at their convenience for free, and the credibility from playing with the big boys. Partners win because they use YouTube to market their broadcast programming to the people in the hopes of creating more business on their TV broadcasts.

These timely innovations in business model, technology and user experience, and partnerships made YouTube an overnight success. As Eric Schmidt, CEO of Google pointed out in the Press Release announcing the acquisition: "Our companies share similar values; we both always put our users first and are committed to innovating to improve their experience. Together, we are natural partners to offer a compelling media entertainment service to users, content owners and advertisers.”

YouTube and Google

Google has announced that YouTube will remain an independent business retaining its distinct brand identity. What is not clear is what Google will do to its own Video service. What Google will provide though is the monetization for YouTube's Video services through its advertiser relationships and global reach. If 1% of the 70 million Videos that are served daily click on a Google served advertisement, this would result in 700,000 daily click-through or 255 million click-through in a year (without accounting for any new growth). And if you take a five year period, it would cost Google $1.29 a click in today's dollar. Or to put it another way, Google can create new revenue of $329 million a year without making any profits (assuming it sells ads at $1.29 a click). A steep price to pay for a Video click? Only time will tell as to how big the new YouTube Video Service becomes under the auspices of Google, and how Google will be able to cash in on its investment and eventually make this a $1 Billion business.

iPod - The Perfect Thing

iPod - The Perfect Thing

Five years ago, Apple engineers used foam core and old fishing weights to craft a model of a new MP3 player. The age of the iPod was about to begin.
By Steven Levy

In mid-October 2001, I received an invitation to one of Steve Jobs' carefully choreographed, exquisitely casual shows. It was to be held at Apple's headquarters in Cupertino, California, on October 23. The most interesting thing about the invitation was the teasing addendum: "Hint: It's not a Mac." Usually, I would have hopped on a plane to see the latest wrinkle in the consistently fascinating saga of Jobs. His return to Apple was a great business story in itself, but what was novel about his whole career was its unapologetic and unprecedented grafting of 1960s values – everything from rock and roll to cracker-barrel Buddhism – into the corporate world. Jobs was a great salesman, a guy who out-suited the suits when it came to mastering the pulleys and levers of global high tech product development and manufacturing, a chief executive of two companies traded on the Nasdaq (Apple and Pixar Entertainment). But I'd also seen him stroll into his boardroom wearing scissor-cut shorts almost up to his balls and a pair of flip-flops. All of this – the austere authority of a Zen poet, the playfulness of Mick Jagger, and the showmanship of David Copperfield – would be on display at this event. And if history was any guide, the product he unveiled would be worth writing about.

But I didn't make it to the show. I wasn't traveling much those days. It was, after all, little more than a month after 9/11, and I, like just about everyone else in New York City, was depressed.

I did, however, follow news of the event carefully. Steve Jobs is maniacal about maintaining total stealth in his operation, but a cat of this magnitude could not be fully bagged, and word was leaking that the "not a Mac" was some kind of digital music player. The prospect did not exactly thrill people. Digital music players – also known as MP3 players, in reference to the encoding algorithm that compresses music into data files – had been around for a few years already, but novelty was their main, if not their only, virtue. They generally held too little music, had impenetrable interfaces, and looked like the cheap plastic toys given to losers at carnival games.

I don't recall being so negative myself: I made plans to write about this new toy, discussing with Apple when we might be able to photograph it. It was sometime in the afternoon of that launch day that the Apple couriers reached my office. They had been racing up and down the Atlantic seaboard spreading the new MP3 players to tech writers. So they didn't have time to do much of anything but leave the box. The packaging was a distinctive cube, with a picture of Jimi Hendrix that evoked the excitement of his volcanic performance at Monterey Pop. Inside was the iPod. It was beautiful.

Before I left the office to play with my new toy, I took my prearranged call from Jobs. He sounded out of breath. It was a quarter after one Cupertino time, and he had been chatting up his new product for hours. As interview subjects go, Jobs is a self-starter. He always has a message to deliver, and he does so with unstinting enthusiasm.

I asked him how many iPods he thought Apple would sell. "I don't do predictions." But he did do proclamations. "iPod," he said, "will be a landmark product."

That night, Microsoft hosted a small dinner in New York for a group of journalists, a prelude to its launch of Windows XP the next day. I have lots of experience talking to Bill Gates and do not break into tears when he yells, "That's the stupidest thing I ever heard!" so the Microsoft PR team seated me next to the chairman.

I brought along my new iPod. At the end of the meal, just as the other guests at the table were pushing away their chairs, I pulled out the iPod and put it in front of Gates.

"Have you seen this yet?" I asked.

Gates went into a zone that recalls those science fiction films where a space alien, confronted with a novel object, creates some sort of force tunnel between him and the object, allowing him to suck directly into his brain all possible information about it. Gates' fingers, racing at Nascar speed, played over the scroll wheel and pushed every button combination, while his eyes stared fixedly at the screen. I could almost hear the giant sucking sound. Finally, after he had absorbed every nuance of the device, he handed it back to me.

"It looks like a great product," he said.

Then he paused a second. Something didn't compute.

"It's only for Macintosh?" he asked.

Yes, it was. (Then.)

Anthony Michael Fadell was on a ski slope in Vail, Colorado, on January 23, 2001, when his cell phone rang. The 32-year-old hardware engineer was taking a rare few days off. He had recently started a small digital-music company and was more than happy to continue with it. The fiercely independent Detroit native liked the control of heading his own firm.

But this call was from Apple. All his life, Fadell had idolized the company. When he was 12, he'd combined his summer earnings as a caddy with a contribution from his grandfather to buy an Apple IIe. An ace programmer, he started three companies before he graduated from the University of Michigan. His first job out of college, in 1992, was at a startup called General Magic, working beside two of the stars of the legendary team that had created the Macintosh, Andy Hertzfeld and Bill Atkinson. It was like joining a basketball team and finding yourself teammates with Larry Bird and Dr. J.

Unfortunately, the General Magic product, a handheld communicator, was a flop. After that, Fadell went on to a weird few years at Philips Electronics. Concerned about its overly staid reputation, the Dutch conglomerate had offered Fadell, still in his twenties, the chance to head its new mobile computing group. He was by far the youngest manager at that level in the entire titanic company. Even if Fadell had had a steady temperament and been mature beyond his years, this would have been controversial. But he embraced the role of execupunk. He'd sometimes show up at work with bleached hair, and at meetings he would blast anyone within earshot. When a Fast Company reporter asked him where he'd be if he'd grown up before computers were invented, he responded, "In jail." Nonetheless, Fadell headed the development of Philips' Windows-based PDA, which sold half a million units. That gave him the idea to create a home digital entertainment device with a hard drive-based jukebox to store thousands of songs. He talked with RealNetworks about developing some of the software – and then accepted a job at Real, figuring he'd have a better chance of shipping a challenging product at a company that still retained a startup mentality. But in part because of a disagreement over whether he'd move to Seattle, he quit after only six weeks.

Now Fadell was developing the idea with his own company, Fuse Networks. But here was Jon Rubinstein, Apple's very top hardware guy, telling him to come in and talk about a project. Fadell took the meeting. Of course, Ruby, as he's known to Apple insiders, couldn't tell him anything about the project, because of the company's near-paranoia about keeping secrets. All Fadell knew was that Apple was offering him an eight-week contract to do something that it thought he was qualified to do. What could he say but yes?

Only after agreeing did he learn that the job was to put together an MP3 music player that would work with Apple's existing iTunes application and would not suck. Essentially, he'd have to build a small computer – because, once you get down to it, that's what an MP3 player is, something with a nice visual interface that runs the database program that stores the digital song files, then performs the high-speed mathematical processes that make those files into the same Jimi Hendrix and Yo-Yo Ma tunes that you'd hear on a CD player. No one mentioned that this product might transform Apple and set the technology world, the business world, and especially the music industry on their heads. Because no one suspected it would.

Apple wanted Fadell because of his expertise in the burgeoning world of handheld components. The company had been focusing on the possible elements in a new MP3 player, particularly the brand-new 1.8-inch hard drive made by Toshiba. Despite its diminutive size, it held 5 gigabytes of data – enough for 1,000 songs.

At the time, the cost and capability of such a component were sort of a crazy joke, one of a series of absurdities unleashed by Moore's law. As a yardstick of how ridiculously compact and capacious this hard drive was, consider the situation when Apple unveiled the original Macintosh in 1984. The computer badly needed a hard drive, but they were so expensive that including it in the package would have almost doubled the $2,500 price. When one finally appeared as a third-party peripheral almost a year later, it was half the size of a shoebox and cost around $2,000. It held 10 megabytes, which seemed like an enormous amount of storage at the time. Ha! The entire capacity of that 1985 disk drive is insufficient to store the MP3 file of Neil Young's "Down by the River."

Now Toshiba had a 5-gig drive so small you could swallow it, with enough capacity to pack in three days' worth of music – a thousand songs. And its cost was measured in tens of dollars, not thousands.

Fadell was assigned a partner in his efforts, a sort of consigliere who would connect him to the sometimes-confusing Cupertino culture. Chosen for the task was Stan Ng, a hardware marketing manager who had been with Apple for six years. Ng and Fadell quickly got to the nub of what was required. "'In your pocket' became the mantra for the product, because that was definitely the size and form factor that hit the sweet spot," Ng says. "There were products out there that were small but held maybe 20 or 30 songs and didn't have great battery life, and other products that had a hard drive but weighed over a pound and didn't fit in your pocket. We wanted to create something that merged the best of both worlds."

Apple demanded total stealth, so on their quest Fadell and Ng would talk to people but not really tell them what they were working on. Not even people inside the company. Eventually, Fadell began to make models of what an Apple MP3 player might look like, cutting pieces out of foam-core boards and gluing them together. He finally came up with one that he felt was ideal: a box slightly bigger than a cigarette case with a sharp screen toward the top end and navigational buttons below. But the model felt too light. He went to his garage and recovered the old tackle box he'd used many years before when he'd gone fishing with his grandfather. Still inside were some fishing weights. After flattening them with a sledgehammer, he stuck them into the model to provide a heft that approximated what the final device might feel like. He showed it to Rubinstein, who was delighted.

Fadell's contract ended in early April, and a meeting was scheduled for him to bring his conclusions to the Apple executive team. He had done his homework, not just on the project but on the politics of presenting to Steve Jobs. He came to the meeting with three different versions. Two of them were sacrificial lambs that he felt would rightfully be rejected, setting the stage for the third one, which he was sure was the perfect solution. Before the meeting, Fadell and Rubinstein hid the mock-up of this favorite under the large wooden bowl that Jobs kept on the long table in the fourth-floor conference room.

The key people were all at the meeting: Rubinstein; iTunes czar Jeff Robbin; Apple's worldwide marketing vice president, Phil Schiller; and, of course, Jobs, who had been in contact with Ruby on the project but had yet to meet Fadell. The session started out with Ng showing the usual sort of slides – stuff about the market potential, the competition, how horrible the current choices were, and the question of whether Apple could innovate. Jobs, as always, kept things moving with his interruptions. Then Fadell took over. He laid potential parts on the table – Toshiba's 1.8-inch hard drive, a small piece of glass for the screen, various battery alternatives, a sample motherboard – and began instructing the group on the finer points of handheld economics, the current pricing curves of memory and hard drive storage, what the latest battery technology was, and the kinds of displays one could use.

Executing the Goldilocks gambit, Fadell showed his first model; it had a big slot that could accept either a hard drive or a flash memory card to hold music. This was a clumsy solution and not well received. Too complicated, Jobs sniffed. Then came the second proposal, a device that would store tunes with dynamic RAM; it would be cheap and hold a bunch of songs, but if the battery died, the songs would vanish and you'd have to reload. That will never sell, grumbled Jobs. Finally, Fadell went back to the table and began grabbing the pieces he'd used to demonstrate what parts were available. As if constructing a Lego device, he snapped them together, creating something that might today be considered iPod-esque, and handed it to Jobs. The silence said, This is more like it. Then it was time to show Jobs the more polished model under the bowl, with the angling weights and mock-ups of buttons on the front to control the software. This time Jobs' pleasure was obvious.

Just right.

There was another surprise to come. Schiller asked, "Can I bring out my thing now?" He left the room and came back with a number of different-size models of a playback device – big ones, tiny ones, in all sorts of shapes. They had one thing in common: a wheel-shaped contraption on the front. The idea, Schiller explained, was that by using a single finger, tracing the circular pathway on the wheel, you could easily scroll through lists – of songs, of artists, of albums. To select something, you'd press the bull's-eye in the center of the wheel. What's more, as your finger moved around, the scrolling speed actually accelerated, so you could go through long lists at a fairly brisk pace.

(Schiller later explained to me that the idea had crystallized at an earlier meeting with Jobs and Rubinstein. "All the other MP3 players had these little Plus and Minus buttons to go down a menu one song at a time. We were going to hold a thousand songs on this thing – you can't hit the Plus button a thousand times! So I figured, if you can't go up, why not go around?")

Jobs asked Fadell if he could build something like Schiller's scroll wheel, and Fadell said he could.

The project was a go.

The formal codename was P-68, but informally, people also used a more evocative term: Dulcimer.

There is no single "father of the iPod." Development was a multitrack process, with Fadell, now on staff, in charge of the actual workings of the device, Robbin heading the software and interface team, Jonathan Ive doing the industrial design, Rubenstein overseeing the project, and Jobs himself rubbernecking as only he could. For specific tasks, Apple drew on experts working elsewhere in the company. Fadell also contracted with key outsiders, notably a San Jose company called PortalPlayer and a small firm of Apple expatriates called Pixo. And, of course, the Apple people had full-contact sessions with Jobs. He would pick up the device and say what he liked and didn't like, and he would fire questions at everyone, pushing hard: "What are you going to do about it?" It was Jobs who told everyone what the device would be called. "He just came in and went, 'iPod,'" says one team member. "We all looked around the room, and that was it. iPod. And we're like, 'Where did that come from?'" (Excellent question, and one that proved increasingly elusive the more I pressed people at Apple. I was finally able to corner Jobs on it, and he said that to the best of his knowledge the name sort of emerged, not exactly in a form of immaculate conception but in a lengthy back-and-forth between him, his marketing people, and TBWAChiatDay. "The ad agency loved it," he told me. But I get the distinct impression that the iPod moniker won out not because of its brilliance but because Jobs had had enough of the naming process and the hour was getting late.)

Sometimes his pronouncements would astound his employees. When one of the designers said that obviously the device should have a power button to turn the unit on and off, he simply said no. And that was it. It was a harsh aesthetic edict on a parallel with his famous refusal to include cursor keys on the original Macintosh keyboard. From Jobs' point of view, all that was needed was forward, back, and pause buttons, arranged around the circumference of the wheel. (After much effort, his team eventually convinced him of the necessity of a fourth button, called Menu, that would move you through the various lists of options.)

In August, the team finally got one of the physical prototypes to play a song. A group of people working late at night took turns listening on a set of headphones from someone's old Sony Walkman. That first song, by the way, was Spiller's "Groovejet (If This Ain't Love)," a house-music dance tune with vocals by the British diva Sophie Ellis-Bextor.

Copy protection wasn't part of iTunes or the iPod, which happily accepted songs in the free-flowing MP3 format. But Jobs was concerned about piracy, so he did take modest steps against it. Until very late in the development phase, the iPod's designers intended not only to let people load songs from their Macintoshes onto the devices but to enable a reverse process: the ability to add songs to a computer from an iPod. But Jobs, convinced that this two-way sync would make it too tempting for people to plug their iPods into a friend's computer to download entire collections of songs, mandated that the sync work only one way. Likewise, Jobs announced one day that iPods would come packaged in an outer wrapping that said: don't steal music. What about other languages? he was asked. "Put multiple languages on it," he said.

Everyone seemed to have a moment of enlightenment when the clouds parted and it was clear that something amazing was emerging. For Jobs, "It all clicked for me when we designed the user interface. We had the wheel, and we started to lay out the menus and argue about this and that, and it took us about a week where we had most of it done, and once you saw the user interface and how easy it was going to be to get around and how well the wheel worked and how well the concepts of the user interface worked, then it was really clear that you'd be able to [navigate through] a thousand songs. Having a thousand songs in your pocket wouldn't be that exciting if you couldn't navigate and access them easily. Once that user interface clicked, it was like, 'Oh my God, this is gonna be so cool.'"

That interface made the iPod experience special even for those who had been intimately involved in designing it. For Stan Ng, the head-slapping moment came when he took his own prototype home for the first time. "I probably had 80 or 90 CDs' worth of music on my Macintosh; transferring down superfast over FireWire and then being able to pick any music, any album, whenever I wanted to was a feeling of freedom, of empowerment. It was just magic. I don't know how else to put it."

While such informal experimentation was the closest thing to market research Apple performed, there were all sorts of tests to make sure that everything worked, especially when the device came into contact with the physical insults it would face from users in the real world. The most fragile piece was the hard drive. "No one had really ever put such a tiny hard drive in a device that was really pocketable," one engineer explains. "So we were doing things like dropping hundreds of disk drives in these models to figure out if they were going to be robust or not." The testers set up robotic arms that methodically dropped the drives – some on their own, some in cases – from different heights to see how far they could fall and survive, like digital crash test dummies. Apple figured that an iPod should be able to withstand a 30-inch tumble, and the dummy disks passed the test.

Just before the launch, the first production iPods arrived, ready for the lucky first wave (like me) who would receive them in advance of the thousands that would be snapped up instantly when Apple began selling them to the public in November 2001.

Looking back on the process, Jobs waxes philosophical. "If there was ever a product that catalyzed Apple's reason for being, it's this," he says. "Because it combines Apple's incredible technology base with Apple's legendary ease of use with Apple's awesome design. Those three things come together in this, and it's like, that's what we do. So if anybody was ever wondering why Apple is on the earth, I would hold up this as a good example."

Co-Creation driving Innovation

Co-Creation driving Innovation

What does Doritos chips, Starwood hotels and Timex watches have in common? According to Gerhard Gschwandtner, Editor and Founder of Selling Power, they are all engaging their customers to co-create. In the latest issue of Selling Power, Gschwandtner talks about the role of co-creation driving innovation in mainstream businesses.

What is Co-Creation?

Gschwandtner summarizes: "Information (online) technology has empowered consumers to share ideas, documents, images, and movies across the forever- expanding digital world. The Internet allows businesses to engage customers in a creative workshop experience." This online engagement with the customers that creates new innovative solutions is Co-Creation.

Doritos and The Super Bowl

What is Doritos doing to co-create with the customers? How about a "story about eating your first Doritos chips or what life is like for the spices on the surface of the chip"? Consumers are invited to submit their 30-second homemade videos on stories about Doritos. Talk about whetting consumers' appetite for Doritos with the growing appetite of homemade videos - it appears that Doritos has created the perfect match. And the best part is the grand prize: the top video will be aired as a commercial during next year's Super Bowl (2007). Five finalists will also be awarded $10,000 each. Doritos wins by rallying hundreds of thousands of consumers to create playful videos about its chips, creating the consumer buzz around Doritos at time of the Super Bowl, and finally showcasing the advertisement in front of about a hundred million people watching the Super Bowl. Co-Creation in motion.

Aloft at Starwood

The next time you want to go to a great hotel, how about just logging online and typing in: www.virtualaloft.com. No need to leave home. Welcome to Aloft Hotel, the new futuristic hotel from Starwood. The virtual hotel invites guests to tour the hotel and get a 360 degree view, walk around the lobby, check into a room, swim in the pool, and even watch a sunset on the rooftop terrace. Starwood has taken the concept of co-creation to the next level (literally) by creating the first virtual hotel online, and simultaneously encouraging the customers to provide feedback and engage with the designers and architects who are building the real hotel.

The real hotel will not open until 2008 - plenty of time for Starwood to gather all the customer inputs and creating something that customers really crave for. What a great concept? For instance, at their website, the designers heard one question a few times on "why there wasn't a door in the bathroom." They immediately responded that "there will be a sliding door in the real hotel" and explained why it was missing in the first place. Co-Creation at work.

Timex and The Future of Time



Timex, as part of its 150th Anniversary celebration, and to demonstrate an ongoing commitment to design and innovation, conducted a global design competition: Timex2154: The Future of Time (2004+150 years=2154). Designers from more than 72 countries explored and visualized personal and portable timekeeping 150 years into the future and submitted 640 entries. An assembled world-class design team evaluated the entries in three categories: wrist-based, wearable, and conceptual, and chose the winners. Timex could not have done this alone (if they would have tried to design a futuristic watch). Instead, they were able to obtain 640 creative ideas from some of the world's best designers in a timely manner. Further, Timex created a leadership position as a Watch company by creating such a campaign and getting the inputs from some of the best designers. Co-Creation driving innovation.

Diversity drives Innovation

Gschwandtner compares the past and the present of customer innovations: "In the past, customers have been limited to communicating their wants and needs in surveys and focus groups; today, brands deploy existing technologies to map their customer’s imagination. Brands no longer view consumers as targets with a wallet, but as co-creators of exciting and profitable solutions." This is a tremendous shift. Rather than simply aiming customers for profits with obsolete products, now you are learning from them in real-time and creating better products that will in turn create profitable customers. And today's customer who is digitally engaged and enjoys personal service would not have it any other way. Gschwandtner aptly quotes the term "Diversity drives Innovation" from the book The Medici Effect by Frans Johansson to demonstrate the effect of Co-Creation.

Bottomline

As Co-Creation demonstrates tangible results, more mainstream businesses will experiment and adopt it - not just technology companies. The best side effect of Co-Creation is it brings you that much closer to your customers and creates a positive business environment. The business should not become overzealous about deploying Co-Creation. It has to make observations and decisions based on sampling size and customer type on whether to go all out with customer inputs or experiment.

iPod - Apple's Best Innovation

iPod - Apple's Best Innovation

Apple is the World's Number One Innovative Company, two years in a row according to BusinessWeek's 2006 list of the world's 25 most innovative companies. BusinessWeek proclaims "their creativity goes beyond products to rewiring themselves." BusinessWeek ranks the innovative companies based on the responses received from over 1,000 global executives of the largest global corporations; survey questions include innovation metrics on process, product and business model innovations.

According to BusinessWeek, innovation today is “much more than new products.” Innovation is also “reinventing business processes and building entirely new markets that meet untapped customer needs.” The ubiquity of the Internet and globalization of the business expand generation of new ideas. Innovation is then “selecting and executing the right ideas and bringing them to market in record time.”

iPod driving Apple to Number One Innovative Company

iPod, powered by Apple, introduced in 2001 and masterminded by Steve Jobs, combines outstanding design, easy-to-use interface, superb performance, and an experience like no other. Apple assumed the world’s number one innovative company position and held it again in 2006 in large part due to the exponential growth of iPod – aptly called the iPod phenomenon. Just ask the tens of millions of fans walking, driving, jogging, exercising, chatting, playing, humming, relaxing, singing, rocking, screaming, and above all enjoying their daily iPod experience. Imagine if they were to miss their iPod for a day, or even for a few hours. iPod is oxygen – pure and simple – the source of life for these millions of fans. Not to mention iPod has become associated with personal status and symbol that speaks of cool, hip, polished, and different. What began as a new product quickly became a revolution. iPod is by far the best commercial innovation the world has seen in the last few years, and perhaps is the best innovation from Apple dating back through its storied history of innovation firsts. Apple one-upped the iPod design innovation by creating new innovations in business model with the launch of iTunes online service enabled by strategic partnerships with the Music, TV and Movie industry.

A Glorious History of Innovations

Apple has created great innovations beginning with the first Apple computer in 1976, Graphical User Interface (GUI) along with the popular Macintosh introduced in 1984, the reliable PowerBook introduced in 1991, the PDA named Newton that created a new industry of handhelds in 1993, the new millennium revolution beginning with the iMac in 1998, the new iBook hot on the heels of the iMac in 1999, the iPod that put an oomph in the MP3 players and essentially changed music as we know it in 2001, iTunes software and Music store service that changed the Music industry business model and made it easy for fans to listen and buy music piecemealed in 2003, iPod mini, iPod (U2 Special Edition) and iPod photo in 2004, iPod shuffle, iPod nano, iPod with Video and Mac Mini in 2005, the new iMac with Intel core Duo processors and the new MacBook with Intel processors in 2006.

Five years of iPod Innovations

2006 marks five years of iPod innovations. Apple's Hardware engineering chief Jon Rubinstein assembled a team of engineers to design and build the first iPod in less than a year, and it was unveiled by CEO Steve Jobs on October 23, 2001 as a Mac-compatible product with a 5GB hard drive that put "1,000 songs in your pocket." Since then, Apple has introduced fourteen different models of iPods in various colors, displaying photos, downloading and playing videos, branded and signed by U2, with numerous forms and shapes, different capacities for holding songs, pictures and videos, with connectors, next generation models with better wheels, and more. For instance, the new iPod video introduced in 2005 was the first iPod that could download and playback full-motion video with a larger color screen and better display resolution – an innovative package under $300 for the base model. Or the innovation in the wheel that is akin to the driving wheel on a car – from an original mechanical scroll wheel to the current touch-sensitive click wheel. According to PC Magazine, “In the years since (2001), the iPod's market share has grown tremendously, iPods have shrunk in size, Apple's iTunes Music Store has taken the lion's share of legal digital music downloads, and the iPod accessory market has exploded and taken on a life of its own. All this has made the iPod as synonymous with "MP3 player" as Kleenex is with facial tissues.”

The love for iPod

Why do people love iPod perhaps more than their spouse, boyfriend, girlfriend or children? It has to do with the simple yet elegant design that makes it extremely easy-to-use (Toyota’s Innovation Factory), exceptional sound, video and imagery, and the amazing experience. The flexibility provided by the iTunes software and service that allows you to try and download any music and video with the click of a button from any computer or the Internet to your iPod. And all the available accessories from wireless headsets, remote controls, beautiful skins, acoustic speakers, to connectors that can literally take your iPod music and videos anywhere – inside the room, in the car, in the office, on the plane, even while taking shower. iPod fans can’t live without their iPods literally. And the search is still on for a music fan that has switched from an iPod to another MP3 player. And there is that small sharing thing: hard-core iPod fans don’t like to share their iPods with others. BYOiPod. Bring your own iPod.

iPod’s Topline

In the latest quarter ending September 2006, Apple sold 8.7 million new iPods, generating $1.5 Billion in sales, a third of Apple’s total quarterly sales. By the end of 2006, there will be over 67 million iPods in the world; Apple is poised to eclipse the 100 million iPods mark in 2007. iPod has revived Apple from the depths in 2001 when annual sales had plummeted to $5.36 Billion and Apple was losing money. Apple’s shares were under $10. Compare this to 2005, when Apple had sales of $13.9 Billion, and profits of over $1 Billion. Apple’s shares have climbed sixteen folds. The Apple machine is kicking into high gear, in large part due to iPod Innovation Revolution. iPod’s halo effect is even evident in the latest quarter when Apple sold more Macs than it has ever sold before: 1.61 million.

The next generation iPods

What innovations can be expected from iPod? Can Apple create jazzier, easier, feature-rich iPods?

How about iPods that beam songs and videos to each other, to a computer or even to a TV? Or iPods that deliver Presentations and Live Videos in team meetings. iPods with GPS Navigation system. iPods that combine as cell phones. iPods that can receive satellite radios. What innovations will Apple bring out next? Steve Jobs indicated in the latest quarterly earnings press release that 2007 will be an exciting year full of great new products. The world will be watching.

Creativity Driving Innovation In Business: Toyota's Innovation Factory

Toyota's Innovation Factory

How does an organization implement one million new creative ideas each year? And become a perennial top ten profitable companies of the world. And achieve market leadership while relentlessly pursuing perfection and delivering some of the best new innovations the world has ever seen.

Welcome to Toyota’s Innovation Factory. The world knows Toyota as the car maker that produces such great brands as Camry, Lexus, Prius, Scion, Rav4 and more. For example, the introduction of the Hybrid car back in 1997 when other car makers had not even put together a design for a hybrid car, much less a concept car.

Matthew E. May, a senior University of Toyota advisor, and the author of “The Elegant Solution: Toyota's Formula for Mastering Innovation” puts forth a passionate perspective on how Toyota creates new innovations at the breakneck speed of over 2,500 new ideas implemented every day. How is this possible? Innovation at Toyota has to do with the history, foundation, guiding principles and practice.

Foundation of Elegance and Innovation

Toyota was founded by Sakichi Toyoda as a handloom company. In 1898, Toyoda created Japan’s first steam-powered loom. Toyota Motors began as Toyota Automatic Loom Works, a company whose looms were of the “highest quality, lowest cost, and easiest to use.” Sound familiar. Hence the term “Elegant Solution” which according to May is about “finding the aha solution to a problem with the greatest parsimony of effort and expense.” And May argues that at Toyota, you get elegance from creativity, simplicity, intelligence, subtlety, economy, and quality. Further, May lays the groundwork for the term Innovation, which according to David Neeleman, founder and CEO of JetBlue means: "Innovation is trying to figure out a way to do something better than it's ever been done before." Indeed. This has become one of the guiding principles at Toyota.

Guiding Principles for Driving Innovation

Three guiding principles drive Innovation and create elegant solutions at Toyota, which were originated and finessed by Toyoda:

1. The Art of Ingenuity

May asserts that in order to succeed in an ever complex business world with competing pressures to innovate amidst competitive pressures and yet manage risks and uncertainty, an individual has to be both an artist and a scientist. Ingenuity creates images of cleverness, resourcefulness, initiative, originality, inventiveness, creativity, skill and even cunning – resulting in innovation. Sound contradictory. The key is to continually ask the question: “Is there a better way?”

This is possible if the individual fully leverages their domain knowledge and expertise, continuously pursues every possible way to innovate and perfect, challenges opposition tactfully, does not accept the status quo, and uses organizational efficiencies to drive new ideas and methods. Toyota has made ingenious vehicles such as Camry, RAV4, 4-Runner, RX which have become perpetual favorites in the market place.

2. The (relentless) Pursuit of Perfection

May argues that for a business to succeed at innovation, it has to rigorously search for an optimal solution – one that yields low-cost, low-risk, high-impact breakthrough. Innovation happens at Toyota through systematic pursuit of perfection at every level, every department, in everything Toyota does. Perfection equates to excellence, precision, flawlessness at Toyota. And it is this chase for perfection that creates better processes, products and services for tomorrow, today. It takes many small steps (Collins - Built to Last) to create sustainable innovation. For example, the Lexus cars made by Toyota epitomize perfection in the form of car design, function, performance, service and total satisfaction.

3. The Rhythm of Fit

May propounds that great innovation has to fit – fit the innovator, the times and the larger system. How can a great innovation shape and then change the attitudes and behaviors of people, the way they think, they work, they live? A change that fits in the current time and environment. For example, the Toyota Prius car. A hybrid car that provides plenty of room in the inside, shows solid performance on the highway, provides all the safety features, and gives great gas mileage and range. Toyota envisioned the changing environment of higher gas costs and pollution that wanted a car which is economical to drive, is environmentally friendly (green innovation), and does not sacrifice the inherent need for roominess, safety and performance.

The three principles create both the policy and framework at Toyota for driving innovation and creating elegant solutions. How would you find and drive innovation at your organization? Here are six ways to find innovation. If you are a technology company, read about how Intuit creates innovations and achieves market leadership using similar principles. May asserts that these three principles are non-negotiable and must be adhered to by everyone at Toyota.

Blocking Innovation

May also talks about the obstacles that hinder sustainable business innovation which Toyota has tactfully avoided through out its history. He calls these innovation blockers “temptations”, which are about taking short cuts, trying to hit a home run every time, creating products too complex that are top loaded with extra dressing, and without a real understanding of the innate customer need.

Here are the three Innovation blockers (does your organization block creativity and innovation? Here are some tips to unblock creativity and innovation) that Toyota has avoided over the years:

1. Swinging For Fences

High risk. High reward. NOT. When a company only focuses on trying to go all out for home runs every time at bat, you will strike out more often than not. The key is to build a sustainable batting average -- lasting innovation, and not just go out swinging every time at bat.

2. Getting Too Clever

Every product manager at one time or the other is guilty of adding all those extra "bells and whistles" that the customer does not care about. This happens when you bow in to competitive pressures, or needs of specific customers that are not indicative of the mass market. The company ends up creating products that customers actually run away from.

3. Solving Problems Frivolously

May calls this the "brainstorm" trap, which is creating something that is out of line with the company’s core values, not serving customer’s true needs, and worse yet, something that is created hastily without rigor and analysis.

Ten Practices for Making Innovation

May showcases the following Ten Practices that Toyota has adopted on its core principles towards making Innovation happen:

1. Let Learning Lead
“Learning and innovation go hand in hand, but learning comes first.” Education and Learning can drive substantial innovation.

2. Learn to See
“Elegant solutions often come from customers -- get out more and live in their world.” The key is to unearth the latent needs of the customers, and perceive the emerging needs.

3. Design for Today
“Focus on clear and present needs, or your great ideas remain just that.” Innovation that drives business in today’s market is likely to get funded and succeed.

4. Think in Pictures
“Make your intentions visual -- you'll surprise yourself with the image.” In Six ways to find innovation, we talked about the need for visual imagery.

5. Capture the Intangible
“The most compelling solutions are often perceptual and emotional.” This is where the product manager needs intuition and the ability to read their customers’ minds.

6. Leverage the Limits
“Restraining forces rule -- resource constraints can spur ingenuity.” It is critical to know what you can deliver, how you can deliver and by when.

7. Master the Tension
“Breakthrough thinking demands something to break through.” In Failures and Stumbles driving innovation, we talked about the five takeaways stimulating innovation. Accept that mistakes will be made.

8. Run the Numbers
“Think for yourself -- temper instinct with insight, focus on facts, and do the math.” A sound technical analysis is critical before you begin a new product innovation. This should take into account such factors as risks, probabilities of success, and lessons learned from past projects.

9. Make Kaizen Mandatory
“Pursuing perfection requires great discipline -- create a standard, follow it, and find a better way.” A process is a must have. Think Six Sigma. Think Rigor at Intuit.

10. Keep It Lean
“Complexity kills -- scale it back, make it simple, and let it flow.” Innovation happens when you can simplify the intended application and make it so easy-to-use that it becomes a no-brainer.

Bottomline:

Toyota has become the dominant car maker today based on large part due to the Innovation Factory. A Factory based on a foundation of creating elegant solutions through three guiding principles, avoiding three “temptations” and driving ten production practices.

"Toyota is becoming a double threat: the world's finest manufacturer and a truly great innovator . . . that formula, a combination of production prowess and technical innovation, is an unbeatable recipe for success."

* Fortune, February 2006

References:

Matthew E. May: “The Elegant Solution: Toyota's Formula for Mastering Innovation”. Free Press. 2006.

09 October 2006

Climatechange: shock report

Climatechange: shock report
Rosslyn Beeby
Monday, 9 October 2006

Leading aid agencies are calling for an urgent review of Australia's immigration program, warning millions of people in the Asia-Pacific region will be left homeless by climate change in the next 40 years.

World Vision chief executive, Reverend Tim Costello said yesterday, "Climate change is emerging as a significant threat to political stability and security in the region.

"The Australian Government cannot hope to win a war on terror in the Asia-Pacific region if it isn't prepared also to wage a war against global warming."

Mr Costello warned Australia would need to assist with relocating and retraining people in developing countries affected by climate change and "develop flexible immigration programs that will help address these needs".

According to a CSIRO report, commissioned by aid and conservation agencies forming the national Climate Change and Development Roundtable, more than 150,000 million people in the Asia-Pacific region would be displaced by rising sea levels by 2050.

It warns that climate change impacts on human security in a region - where 60 per cent of the world's population lives - could be "sufficiently severe" to induce or contribute to violence and armed conflict threatening national and regional security.

Regional impacts would include intensification of tropical storms and cyclones, water shortages, rising sea levels, increased spread of dengue fever and malaria, crop failures, food scarcity and threats to national economic productivity.

The report, by scientists with CSIRO's Marine and Atmospheric Research division, says coastal areas most at risk from rising sea levels were low-lying river deltas in Vietnam, China, India, Pakistan and Bangladesh. Among Pacific Island nations, Tonga and Papua New Guinea have both recorded sea level rises of 8mm per year over the past 12 years. The Federated States of Micronesia has recorded a rise of 21mm per year since 2001.

"With 30-50cm of sea-level rise, the economic costs in the Asia-Pacific region rise to the hundreds of millions to billions of dollars per year and over 100,000 kilometres of coastline experiences the effects," the reports says.

It warns "there is little room for optimism", with climate models predicting temperatures are likely to warm more quickly in the arid areas of northern Pakistan, western China and India.

China could lose up to 70 per cent of its high-altitude forests and some Pacific Island nations would lose more than 50 per cent of coastal mangrove ecosystems.

The report says hotter, drier conditions caused by climate change have already caused an increase in the frequency and severity of wildfires in Asia. Fires associated with higher temperatures caused by the 1997-98 El Nino released 2.1 billion tons of carbon into the Earth's atmosphere, with 60 per cent coming from wildfires in South-East Asia.

The Australian Conservation Foundation's Asia-Pacific program coordinator Lee Tan said villages in rainforest areas of Papua New Guinea had received no rain for the past four months and were experiencing water shortages. "These are rainforest areas, and they are in drought," she said. "Australia is the region's biggest contributor to greenhouse emissions and therefore we have an obligation to support countries that are being affected by climate change."

According to the CSIRO report, Australia has the highest per capita emissions of carbon dioxide - 17.2 tonnes for each person - for the Asia Pacific region.

08 September 2006

Future Trends For Nanotechnology and the Application of Nanotechnology in Solar Cells, Nanofibres, S

Future Trends For Nanotechnology and the Application of Nanotechnology in Solar Cells, Nanofibres, S: "Future Trends For Nanotechnology and the Application of Nanotechnology in Solar Cells, Nanofibres, Sensors, Ultra Light Materials and Corrosion Prevention
Topics Covered

Background

Future Trends

Solar Cells

Nanofibres

Sensors

Spending and Investment

Ultra Light Materials

Corrosion and Corrosion Prevention
Background

Materials scientists and engineers have made significant developments in the improvement of methods of synthesis of nanomaterial solids. A brief review of future trends in nanotechnology developments is given in this article.
Future Trends

Unprecedented opportunities are arising for re-engineering existing products. For example, cluster of atoms (nanodots, macromolecules), nanocrystalline structured materials (grain size less than 100 nm), fibres less than 100 nm in diameter (nanorods and nanotubes), films less than 100 nm in thickness provide a good base to develop further new nanocomponents and materials.

The buckyball (C60) has opened up a excellent field of chemistry and material science with many exciting applications because of its ability to accept electrons. Carbon nanotubes have shown a promising potential in the safe, effective and risk free storage of hydrogen gas in fuel cells, increasing the prospects of wide uses of fuel cells and replacement of internal combustion engine. The potential of nanotubes can"

Cancer research breakthrough

Cancer research breakthrough: "Cancer research breakthrough

[Posted: Fri 08/09/2006]

New research has identified the majority of the mutated genes that cause breast and colorectal cancers. This finding could eventually lead to new ways to diagnose and treat two of these two cancers.

The research, which has identified the first genetic map for these cancers, has been described by experts as 'groundbreaking' and 'truly remarkable'.

The researchers say the new finding help adjust cancer treatment for each patient and treat their cancer more effectively.

The scientists at Johns Hopkins at Baltimore expected to find a small number of cancer-causing cells. Instead, they found nearly 200. Breast and colorectal cancer are major killers of women in Ireland and worldwide.

In the past, chemotherapy for cancer has attacked both cancerous and healthy cells. Newer treatments have targeted specific cancer genes.

These therapies, however, only work with a small proportion of cancer patients and it is known that many more genes are responsible for cancer developing.

The new discovery, it is hoped to tackle more genes and a larger number of patients, in addition to making therapy more personalised according to a person’s genetic make-up.

In Ireland there are 2,000 new cases of breast cancer each year and 600 deaths, while one in 20 Irish men and one in 32 women will develop colorectal cancer.

The researc"